IPF is a severe life-threatening lung disease characterized by a progressive and irreversible decline in lung function.
The most common symptoms of IPF are shortness of breath and a dry persistent cough. As the disease progresses, the breathing difficulties and lack of oxygen to the tissue leads to a wide variety of symptoms such as weight loss, aching muscles, chronic fatigue and, in many cases, eventually death.
Patients with IPF generally have a poor prognosis with a mean survival between two to five years, and there is a high unmet medical need for safe and well-tolerated medicines that can halt, and potentially reverse, its progression. Galecto is developing an inhaled galectin-3 inhibitor – GB0139. In a phase IIa trial in IPF, GB0139 was safe and well tolerated, and demonstrated unprecedented effects on important biomarkers of disease activity.
Galectins have been implicated in a number of immune-inflammatory mechanisms that can drive tissue injury, fibrosis, and tumor progression. For example, macrophages are an important source of gal-3 which are then activated and able to alter the micro-environment to cause tissue damage, and ultimately scarring (fibrosis).
Galecto, Inc. develops small molecules for the treatment of severe diseases, including fibrosis and cancer. The company, founded in 2011, builds on more than 10 years of research centering on the role of galectin-3 and LOXL-2, and the use of modulators of these proteins to treat fibrosis-related diseases and cancer. Combined with a strong patent estate, these assets give Galecto a unique therapeutic platform.