Galecto, Inc. develops small molecules for the treatment of cancer and severe liver diseases. The company is built on nearly 15 years of research centering on the role of galectin-3 and the use of modulators of these proteins to treat cancer and severe liver diseases. These assets, combined with BRM-1420, a novel dual ENL-YEATS / FLT3 inhibitor, provide Galecto with a unique therapeutic platform.
Small molecule fibrosis inhibitors: at the heart of our R&D strategy
Galecto is committed to developing novel therapeutics for cancer and severe liver diseases with a high unmet medical need.
ENL-YEATS and FLT3 are involved in key oncology pathways. Inhibition of those domains has shown potent activity, and inhibition of cell proliferation, in multiple genetic subsets of acute myeloid leukemia (AML).
Fibrosis is a severe scarring process that occurs in many chronic diseases of the liver, kidneys, heart, joints and eye. It can severely disrupt organ functions, leading to irreversible organ failure, and the need for transplantation, and can also be fatal in some cases.
Galecto’s small molecule pipeline targets a key protein involved in the fibrotic process, galectin-3.