Fibrosis

Fibrosis is a serious complication of several diseases, as it weakens the function of various organs such as the lungs, kidneys, liver and the gastrointestinal tract. Idiopathic Pulmonary Fibrosis (IPF) has been selected as the lead indication, since early intervention may stop progression and prevent organ failure.

subpage_image

Galectin-3 plays key roles in fibrosis

- Galectin-3 is central in macrophage and fibroblast differentiation.
- It promotes myofibroblast activation and differentiation and promotes collagen synthesis.
- Galectin-3 promotes activation of macrophages which in turn cause activation of myofibroblasts.
- Mice deficient in galectin-3 develop much less severe fibrosis in animal models of liver, renal and pulmonary fibrosis.